Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis.

The article discusses the extracellular matrix (ECM), a major component of the tumor microenvironment, promotes local invasion to drive metastasis. Topics include a method to study whole-tissue ECM effects from disease states associated with metastasis on tumor cell phenotypes and identify the individual ECM proteins; and triple-negative breast cancer, representing 15 to 20% of breast cancer cases, has aggressive.