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HSB-1/HSF-1 pathway modulates histone H4 in mitochondria to control mtDNA transcription and longevity.
- Source :
-
Science Advances . 10/21/2020, Vol. 6 Issue 43, p1-17. 17p. - Publication Year :
- 2020
-
Abstract
- The article discusses Heat shock factor–1 (HSF-1) has a master regulator of stress responses across taxa. Topics include overexpression of HSF-1 or genetic ablation of conserved negative regulator, heat shock factor binding protein 1, results in robust life-span extension in Caenorhabditis elegans; and the rate of aging in multicellular organisms has determined by evolutionarily conserved cellular and metabolic processes.
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 6
- Issue :
- 43
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 146645803
- Full Text :
- https://doi.org/10.1126/sciadv.aaz4452