Back to Search
Start Over
Novel biocompatible and antimicrobial supramolecular O-carboxymethyl chitosan biguanidine/zinc physical hydrogels.
- Source :
-
International Journal of Biological Macromolecules . Nov2020, Vol. 163, p649-656. 8p. - Publication Year :
- 2020
-
Abstract
- Zinc crosslinked supramolecular hydrogels from O -carboxymethyl chitosan biguanidine were successfully prepared. The structures of the prepared hydrogels were verified by 1H NMR, FTIR and XRD. FE-SEM verified the porous structure of hydrogels especially at high contents of Zn2+ ions. The integral procedure decomposition temperatures calculated from TGA curves showed that the thermal stability was increased upon increasing the content of Zn2+ ions. Cytotoxicity assays confirmed that the amounts of Zn2+ ions released from hydrogels were below the toxic level towards a breast cancer cell line (MCF-7). The prepared hydrogels exhibited a significant microbial inhibition towards different species of bacteria and fungi, particularly at high Zn contents. Based on the obtained interesting data, the prepared zinc/ O -carboxymethyl chitosan biguanidine could be used in drug delivery and biomedical applications. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01418130
- Volume :
- 163
- Database :
- Academic Search Index
- Journal :
- International Journal of Biological Macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 146534582
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.07.029