Back to Search
Start Over
Synthesis and Anticoagulant Activity of New Ethylidene and Spiro Derivatives of Pyrrolo[3,2,1-ij]quinolin-2-ones.
- Source :
-
Russian Journal of Organic Chemistry . Sep2020, Vol. 56 Issue 9, p1550-1556. 7p. - Publication Year :
- 2020
-
Abstract
- The reaction of pyrrolo[3,2,1-ij]quinoline-1,2-diones with methyl (het)aryl ketones gave the corresponding 1-(het)arylmethylidenepyrroloquinolin-2-ones, and 1,3-dipolar cycloaddition of the latter to azomethine ylide generated from sarcosine and paraformaldehyde afforded 4-acyl-1,4′,4′,6′-tetramethylspiro[pyrrolidine-3,1′-pyrrolo[3,2,1-ij]quinolin]-2′(4′H)-ones. The synthesized compounds were evaluated for inhibitory activity against blood coagulation factors Xa and XIa. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD coagulation factor X
*ANTICOAGULANTS
*ISOXAZOLIDINES
Subjects
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 56
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 146532837
- Full Text :
- https://doi.org/10.1134/S1070428020090080