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Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
- Source :
-
Biochemical & Biophysical Research Communications . Nov2020, Vol. 533 Issue 1, p195-200. 6p. - Publication Year :
- 2020
-
Abstract
- The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed. • Silver nanoparticles inhibit extracellular SARS-CoV-2. • 2–15 nm size particles showed robust inhibition of SARS-CoV-2. • SARS-CoV-2 was potently inhibited at concentrations above 1 ppm. • Naked Silver nanoparticles exhibited cytotoxicity from 20 ppm onwards. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SARS-CoV-2
*SILVER nanoparticles
*COLLOIDAL silver
*NANOPARTICLES
*COVID-19
Subjects
Details
- Language :
- English
- ISSN :
- 0006291X
- Volume :
- 533
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Biochemical & Biophysical Research Communications
- Publication Type :
- Academic Journal
- Accession number :
- 146496242
- Full Text :
- https://doi.org/10.1016/j.bbrc.2020.09.018