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双酚 A 激活 PI3K/AKT 通路促进子宫内膜癌细胞增殖的研究.
- Source :
-
Journal of International Obstetrics & Gynecology . Jun2019, Vol. 46 Issue 3, p259-261. 3p. - Publication Year :
- 2019
-
Abstract
- Objective:To explore the mechanism of bisphenol A on the proliferation in human endometrial cancer cells (Ishikawa and RL952) via PI3K/AKT signaling pathway. Methods:CCK8 assay was used to detect the proliferation in Ishikawa and RL952 cells, and Western blotting was applied to observe the expression of phosphorylation-AKT. Results:Ishikawa and RL952 cells proliferation increased significantly with treatment of 1 μmol/L BPA after 48 h, and cell proliferation was (0.758±0.023) and (0.692±0.042) respectively (P<0.01). The proliferation effect decreased when BPA was more than 1 μmol/L. Ishikawa and RL952 cells did not increase after treated for 24 h. Cytotoxic effects were showed after BPA treated for 72 h. After 1 μmol/L BPA treated for 48 h, p-AKT expression was increased significantly compared with controls (P<0.05). When PI3K was blocked by LY294002, p- AKT expression was decreased, but it is not significant compared to controls (P>0.05). Conclusions:Bisphenol A induced endometrial cancer cell proliferation by activating PI3K/AKT pathway. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Chinese
- ISSN :
- 16741870
- Volume :
- 46
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of International Obstetrics & Gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 146416378