The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Authors :: Scattolin, Thomas
Bortolamiol, Enrica
Palazzolo, Stefano
Caligiuri, Isabella
Perin, Tiziana
Canzonieri, Vincenzo
Demitri, Nicola
Rizzolio, Flavio
Cavallo, Luigi
Dereli, Busra
Mane, Manoj V.
Nolan, Steven P.
Visentin, Fabiano
Source :: Chemical Communications. 10/18/2020, Vol. 56 Issue 81, p12238-12241. 4p.
Publication Year :: 2020
Abstract: A new dinuclear Pd(I) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin. [ABSTRACT FROM AUTHOR]

Subjects :: *OVARIAN cancer
*CELL lines
*CANCER cells
*PALLADIUM compounds
*LIGANDS (Chemistry)
*METALS

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