Analiza zaburzeń neuropsychiatrycznych wywołanych infekcją Tropheryma whipplei.

Whipple’s disease is a rare, chronic systemic infection caused by gram-positive Tropheryma whipplei actinobacterium. So far, the reasons for the Tropheryma whipplei infection have not been explained. Clinical symptoms are non-specific and may suggest other diseases, mainly gastrointestinal disease. Nervous system symptoms such as personality disorders, behavioral disorders, depressive symptoms and disturbances of consciousness are also observed.The aim of the study is to collect information on neuropsychological disorders found in Whipple’s disease.Central nervous system (CNS) involvement can take place in three cases: classic form, in the relapse of previously treated classic form (with changes in the digestive system) and in isolated CNS infection (without evidence of gastrointestinal involvement by T. whipplei). Neurological disorders resulting from CNS involvement are variable and may be similar to other diseases of the nervous system. Treatment is difficult due to the long-term course of the disease and non-specificity of its symptoms, which is why the problem is the selection of effective pharmacotherapy. Untreated disease results in worsening neuropsychological disorders. Pharmacotherapy involves the use of antibiotics. The use of antibacterial therapy reduces the risk of recurrence of clinical symptoms. [ABSTRACT FROM AUTHOR]