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Effect of long-term omega-3 supplementation and a lifestyle multidomain intervention on intrinsic capacity among community-dwelling older adults: Secondary analysis of a randomized, placebo-controlled trial (MAPT study).
- Source :
-
Maturitas . Nov2020, Vol. 141, p39-45. 7p. - Publication Year :
- 2020
-
Abstract
- <bold>Objectives: </bold>To investigate the effect of omega-3 (ω-3) polyunsaturated fatty acid supplementation and a multidomain intervention (MI) (physical activity counselling, cognitive training and nutritional advice) among community-dwelling older adults on levels of intrinsic capacity (IC), a construct recently proposed by the World Health Organization.<bold>Study Design: </bold>Secondary analysis from the factorial-design 3-year Multidomain Alzheimer Preventive Trial (MAPT) with 1445 subjects (64.2 % female, mean age 75.3 years, SD = 4.4) randomized to one group of MI plus ω-3 (800 mg docosahexaenoic acid and 225 mg eicosapentaenoic acid/day); MI plus placebo; ω-3 supplementation alone; or placebo alone. Data collection was held between 2008 and 2014.<bold>Main Outcome Measures: </bold>IC domains were examined with the Geriatric Depression Scale (psychological); Short Physical Performance Battery (mobility); Z-score combining four tests (cognitive function); and handgrip strength (vitality). All domains were combined into a composite IC Z-score.<bold>Results: </bold>After 3 years, IC Z-score decreased among all groups when time was considered continuous (MI plus ω-3: -0.16, 95 %CI: -0.22 to -0.10; MI alone: -0.13, 95 %CI: -0.19 to -0.07; ω-3 alone: -0.19, 95 %CI: -0.25 to -0.10; placebo: -0.20, 95 %CI: -0.26 to -0.14; all p < 0.0001). There were no significant differences between groups. In a sensitivity analysis with categorical time, significant within-group declines were first identified at 24 months for all groups.<bold>Conclusions: </bold>This trial designed to improve cognitive function was unable to find effects of the intervention on the composite IC Z-score. Further investigations are needed, especially trials providing stronger interventions (such as exercise training and a controlled diet) and also embracing the sensorial domain of IC. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OLDER people
*SECONDARY analysis
*UNSATURATED fatty acids
*GERIATRIC Depression Scale
*DOCOSAHEXAENOIC acid
*ALZHEIMER'S disease prevention
*THERAPEUTIC use of omega-3 fatty acids
*LIFESTYLES
*GRIP strength
*RESEARCH
*RANGE of motion of joints
*RESEARCH methodology
*COGNITION
*GERIATRIC assessment
*EVALUATION research
*MEDICAL cooperation
*EICOSAPENTAENOIC acid
*DIETARY supplements
*COMPARATIVE studies
*RANDOMIZED controlled trials
*OMEGA-3 fatty acids
*INDEPENDENT living
*EXERCISE
*RESEARCH funding
*LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 03785122
- Volume :
- 141
- Database :
- Academic Search Index
- Journal :
- Maturitas
- Publication Type :
- Academic Journal
- Accession number :
- 146324179
- Full Text :
- https://doi.org/10.1016/j.maturitas.2020.06.012