Predictors of recurrence following laparoscopic radical hysterectomy for early-stage cervical cancer: A multi-institutional study.

To assess predictors of recurrence following laparoscopic radical hysterectomy (LRH) for apparent early stage cervical cancer (CC). This is a retrospective multi-institutional study reviewing data of consecutive patients who underwent LRH for FIGO 2009 stage IA1 (with lymphovascular space invasion (LVSI)), IA2 and IB1(≤4 cm) CC, between January 2006 and December 2017. The following histotypes were included: squamous, adenosquamous, and adenocarcinoma. Multivariable models were used to estimate adjusted odds ratio (OR) and corresponding 95% CI. Factors influencing disease-free survival (DFS) and disease-specific survival (DSS) were also explored. 428 patients were included in the analysis. With a median follow-up of 56 months (1–162) 54 patients recurred (12.6%). At multivariable analysis, tumor size (OR:1.04, 95%CI:1.01–1.09, p =.02), and presence of cervical residual tumor at final pathology (OR: 5.29, 95%CI:1.34–20.76, p =.02) were found as predictors of recurrence; conversely preoperative conization reduced the risk (OR:0.32, 95%CI:0.11–0.90, p =.03). These predictors remained significant also in the IB1 subgroup: tumor size: OR:1.05, 95%CI:1.01–1.09, p =.01; residual tumor at final pathology: OR: 6.26, 95%CI:1.58–24.83, p =.01; preoperative conization: OR:0.33, 95%CI:0.12–0.95, p =.04. Preoperative conization (HR: 0.29, 95%CI: 0.13–0.91; p =.03) and the presence of residual tumor on the cervix at the time of surgery (HR: 8.89; 95%CI: 1.39–17.23; p =.01) independently correlated with DFS. No independent factors were associated with DSS. In women with early stage CC the presence of high-volume disease at time of surgery represent an independent predictor of recurrence after LRH. Conversely, preoperative conization and the absence of residual disease at the time of surgery might play a protective role. • High-volume disease at time of surgery was an independent predictor of recurrence after laparoscopic radical hysterectomy. • Absence of residual tumor at final pathology had a protective role following laparoscopic surgery for early-stage disease. • Preoperative conization positively influenced disease-free survival in IA1(positive LVSI) – IB1cervical cancer. [ABSTRACT FROM AUTHOR]