Vertebral stiffness measured via tomosynthesis-based digital volume correlation is strongly correlated with reference values from micro-CT-based DVC.

• Current techniques for assessing vertebral fracture risk are limited in accuracy. • DTS-DVC allows for clinical assessment of vertebral bone deformation. • Displacement spatial distributions qualitatively agreed between DTS-DVC and μCT-DVC. • DTS-DVC derived displacement and stiffness were strongly correlated with μCT values. • Results support use of DTS-DVC for clinical evaluation of vertebral bone quality. Digital tomosynthesis (DTS) is a clinically available modality that allows imaging of a patient's spine in supine and standing positions. The purpose of this study was to establish the extent to which vertebral displacement and stiffness derived from DTS-based digital volume correlation (DTS-DVC) are correlated with those from a reference method, i.e., microcomputed tomography-based DVC (μCT-DVC). T11 vertebral bodies from 11 cadaveric donors were DTS imaged twice in a nonloaded state and once under a fixed load level approximating upper body weight. The same vertebrae were µCT imaged in nonloaded and loaded states (40 μm voxel size). Vertebral displacements were calculated at each voxel using DVC with pairs of nonloaded and loaded images, from which endplate-to-endplate axial displacement (D DVC) and vertebral stiffness (S DVC) were calculated. Both D DVC and S DVC demonstrated strong positive correlations between DTS-DVC and μCT-DVC, with correlations being stronger when vertebral displacement was calculated using the median (R2=0.80; p <0.0002 and R2=0.93; p <0.0001, respectively) rather than average displacement (R2=0.63; p <0.004 and R2=0.69; p <0.002, respectively). In conclusion, the demonstrated relationship of DTS-DVC with the μCT standard supports further development of a biomechanics-based clinical assessment of vertebral bone quality using the DTS-DVC technique. [ABSTRACT FROM AUTHOR]