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Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease.
- Source :
-
Biomaterials . Nov2020, Vol. 260, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications. The combination of brain-targeted black phosphorus nanostructure and near-infrared irradiation could increase BBB permeability in vitro and in vivo , thereby offering significant anti-Parkinsonian efficacy. Image 1 [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD-brain barrier
*PARKINSON'S disease
*PHOSPHORUS
*LACTOFERRIN
Subjects
Details
- Language :
- English
- ISSN :
- 01429612
- Volume :
- 260
- Database :
- Academic Search Index
- Journal :
- Biomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 145994824
- Full Text :
- https://doi.org/10.1016/j.biomaterials.2020.120339