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Unravelling the interplay between hyperkalaemia, renin-angiotensin-aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry.

Authors :
Rossignol, Patrick
Lainscak, Mitja
Crespo‐Leiro, Maria G.
Laroche, Cécile
Piepoli, Massimo F.
Filippatos, Gerasimos
Rosano, Giuseppe M.C.
Savarese, Gianluigi
Anker, Stefan D.
Seferovic, Petar M.
Ruschitzka, Frank
Coats, Andrew J.S.
Mebazaa, Alexandre
McDonagh, Theresa
Sahuquillo, Ana
Penco, Maria
Maggioni, Aldo P.
Lund, Lars H.
Christopher Peter Gale, GB
Branko Beleslin, RS
Source :
European Journal of Heart Failure. Aug2020, Vol. 22 Issue 8, p1378-1389. 12p. 1 Chart, 5 Graphs.
Publication Year :
2020

Abstract

<bold>Aims: </bold>We assessed the interplay between hyperkalaemia (HK) and renin-angiotensin-aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal.<bold>Methods and Results: </bold>The ESC-HFA-EORP Heart Failure Long-Term Registry was used. Among 9222 outpatients (HF with reduced ejection fraction: 60.6%, HF with mid-range ejection fraction: 22.9%, HF with preserved ejection fraction: 16.5%) from 31 countries, 16.6% had HK (≥5.0 mmol/L) at baseline. Angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) was used in 88.3%, a mineralocorticoid receptor antagonist (MRA) in 58.7%, or a combination in 53.2%; of these, at ≥50% of target dose in ACEi: 61.8%; ARB: 64.7%; and MRA: 90.3%. At a median follow-up of 12.2 months, there were 789 deaths (8.6%). Both hypokalaemia and HK were independently associated with higher mortality, and ACEi/ARB prescription at baseline with lower mortality. MRA prescription was not retained in the model. In multivariable analyses, HK at baseline was independently associated with MRA non-prescription at baseline and subsequent discontinuation. When considering subsequent discontinuation of RAASi (instead of baseline use), HK was no longer found associated with all-cause deaths. Importantly, all RAASi (ACEi, ARB, or MRA) discontinuations were strongly associated with mortality.<bold>Conclusions: </bold>In HF, hyper- and hypokalaemia were associated with mortality. However, when adjusting for RAASi discontinuation, HK was no longer associated with mortality, suggesting that HK may be a risk marker for RAASi discontinuation rather than a risk factor for worse outcomes. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13889842
Volume :
22
Issue :
8
Database :
Academic Search Index
Journal :
European Journal of Heart Failure
Publication Type :
Academic Journal
Accession number :
145967664
Full Text :
https://doi.org/10.1002/ejhf.1793