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Prevalence and Risk Factors of Moderate-to-Severe Hepatic Steatosis in Human Immunodeficiency Virus Infection: The Copenhagen Co-morbidity Liver Study.
- Source :
-
Journal of Infectious Diseases . 10/15/2020, Vol. 222 Issue 8, p1353-1362. 10p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>People with human immunodeficiency virus (PWH) may be at risk of nonalcoholic fatty liver disease. We compared the prevalence of moderate-to-severe hepatic steatosis (M-HS) in PWH with human immunodeficiency virus (HIV)-uninfected controls and determined risk factors for M-HS in PWH.<bold>Methods: </bold>The Copenhagen Co-Morbidity in HIV Infection study included 453 participants, and the Copenhagen General Population Study included 765 participants. None had prior or current viral hepatitis or excessive alcohol intake. Moderate-to-severe hepatic steatosis was assessed by unenhanced computed tomography liver scan defined by liver attenuation ≤48 Hounsfield units. Adjusted odds ratios (aORs) were computed by adjusted logistic regression.<bold>Results: </bold>The prevalence of M-HS was lower in PWH compared with uninfected controls (8.6% vs 14.2%, P < .01). In multivariable analyses, HIV (aOR, 0.44; P < .01), female sex (aOR, 0.08; P = .03), physical activity level (aOR, 0.09; very active vs inactive; P < .01), and alcohol (aOR, 0.89 per unit/week; P = .02) were protective factors, whereas body mass index (BMI) (aOR, 1.58 per 1 kg/m2; P < .01), alanine transaminase (ALT) (aOR, 1.76 per 10 U/L; P < .01), and exposure to integrase inhibitors (aOR, 1.28 per year; P = .02) were associated with higher odds of M-HS.<bold>Conclusions: </bold>Moderate-to-severe hepatic steatosis is less common in PWH compared with demographically comparable uninfected controls. Besides BMI and ALT, integrase inhibitor exposure was associated with higher prevalence of steatosis in PWH. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV infections
*FATTY degeneration
*FATTY liver
*PHYSICAL activity
*ALANINE aminotransferase
*VIRAL hepatitis
*HIV infection epidemiology
*RESEARCH
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*DISEASE prevalence
*ODDS ratio
*BODY mass index
*ENZYME inhibitors
*COMORBIDITY
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 222
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 145887305
- Full Text :
- https://doi.org/10.1093/infdis/jiaa246