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THE SPECIFICITY OF SKIN-SENSITIZING ANTIBODIES IN THE GUINEA-PIG.
- Source :
-
Clinical & Experimental Immunology . May70, Vol. 6 Issue 5, p741-751. 11p. - Publication Year :
- 1970
-
Abstract
- In this paper the specificity of the skin-reactive guinea-pig immunoglobulin in the homologous PCA test has been reconsidered. Extensive purification of this immunoglobulin by chromatographic methods results in the isolation of a small fraction or medium speed immunoglobulins that contains all skin reactivity. No correlation could be found with the 7S immunoglobulins IgGγ1 and Igγ1A suggesting a separate class of biologically active immunoglobulins. The PCA active antibody belongs to either an IgG subclass or is a heat stable homocytotropic antibody. Rabbit and chicken antisera against isolated fractions of guinea-pig immunoglobulins show the existence of 7S subclasses. Some suggestions for a revised nomenclature are given. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 6
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14587886