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Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis in the Han Chinese population.
- Source :
-
Infection, Genetics & Evolution . Oct2020, Vol. 84, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Interleukin-6 (IL-6) plays an important role in chronic inflammation. Thus, we aimed to investigate the effects of IL-6 polymorphisms on predicting the progression of hepatitis B virus (HBV)-r elated liver cirrhosis. A cross-sectional study was conducted to analyse IL-6 polymorphisms and serum levels of IL-6 in HBV-infected patients at different clinical phases and in healthy controls. IL-6 polymorphisms were detected by the TaqMan PCR method, and plasma IL-6 levels were assessed by ELISA. Our analysis included 182 chronic hepatitis B (CHB) patients, 190 HBV-infected liver cirrhosis cases, 125 inactive HBsAg carriers, and 246 healthy controls. Seven SNPs in IL-6 including rs10499563, rs17147230, rs1800796, rs2069837, rs1524107, rs2066992, and rs2069852 were analysed. In a haplotype analysis between HBV-infected liver cirrhosis cases and CHB patients, inactive HBV carriers or healthy controls, haplotype CT in block 1 and haplotype GGCGG in block 2 were associated with liver cirrhosis (P <0.05). Moreover, the genotype or allele frequencies were significantly different in IL-6 rs10499563 and rs2069837 when HBV-infected liver cirrhosis patients were compared with CHB patients, inactive HBV carriers or healthy controls. A further study found that compared with that in the healthy controls, inactive HBV carriers or CHB patients, plasma IL-6 was elevated in HBV-infected liver cirrhosis patients. In conclusion, the IL-6 rs10499563 and rs2069837 polymorphisms are associated with incidence of liver cirrhosis may through their effects on IL-6 expression and these two single nucleotide polymorphisms can be used as potential prognostic markers of HBV-related liver cirrhosis. • The IL-6 rs10499563 and rs2069837 polymorphisms were associated with incidence of liver cirrhosis in a Han Chinese population. • Plasma IL-6 levels were remarkably higher in the HBV-cirrhotic group than in the other group. • Correlation between functional SNPs in whole IL-6 gene and liver cirrhosis was firstly explored in Chinese Han Population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15671348
- Volume :
- 84
- Database :
- Academic Search Index
- Journal :
- Infection, Genetics & Evolution
- Publication Type :
- Academic Journal
- Accession number :
- 145756637
- Full Text :
- https://doi.org/10.1016/j.meegid.2020.104331