Reprogramming competence of OCT factors is determined by transactivation domains.

The article discusses OCT4 playing an essential role in reprogramming. Topics include OCT6-based reprogramming does not the mesenchymal-epithelial transition but is attenuated the delayed activation of the pluripotency network in comparison with OCT4-based reprogramming; and creating a series of reciprocal domain-swapped chimeras and mutants across all OCT factors.