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Heritability of subfertility among Danish twins.
- Source :
-
Fertility & Sterility . Sep2020, Vol. 114 Issue 3, p618-627. 10p. - Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>To investigate the relative contribution of genetic and environmental components to subfertility.<bold>Design: </bold>Twin design using a quantitative genetic liability threshold model that splits the variation of subfertility into additive genetic effects, common environmental effects, and unique environmental effects.<bold>Setting: </bold>Not applicable.<bold>Patients: </bold>A total of 9053 Danish monozygotic and dizygotic same-sex twins aged 18+ years from nationwide twin surveys (twins born 1931-1976).<bold>Intervention: </bold>Not applicable.<bold>Main Outcome Measures: </bold>Time to pregnancy (TTP) restricted to first pregnancy as a binary outcome, with a cut-off point of 10 months.<bold>Results: </bold>Based on the Akaike information criterion, a model including additive genetic and unique environmental factors resulted in the best model fit. For females, the relative contribution of additive genetic factors to TTP was 28% (95% confidence interval [CI] 15%, 41%), whereas unique environmental factors explained 72% (95% CI 59%, 85%). For males, additive genetic factors explained 4% (95% CI 0%, 22%) of the variation in TTP, while unique environmental factors accounted for 96% (95% CI 78%, 100%). Results were overall similar for the crude model and consistent across surveys.<bold>Conclusion: </bold>Unique environmental factors explain most of the observed variation in subfertility, when measured as waiting time to pregnancy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TWINS
*AKAIKE information criterion
*HERITABILITY
*ENVIRONMENTAL auditing
*PREGNANCY
*RESEARCH
*GENETICS
*CROSS-sectional method
*RESEARCH methodology
*ECOLOGY
*MEDICAL cooperation
*EVALUATION research
*INFERTILITY
*RISK assessment
*SEX distribution
*COMPARATIVE studies
*FERTILITY
*DISEASE susceptibility
*PHENOTYPES
Subjects
Details
- Language :
- English
- ISSN :
- 00150282
- Volume :
- 114
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Fertility & Sterility
- Publication Type :
- Academic Journal
- Accession number :
- 145628158
- Full Text :
- https://doi.org/10.1016/j.fertnstert.2020.03.014