UTJECAJ ČIMBENIKA ANGI OGENEZE NA RAZVOJ POSTELJICE.

This review article brings into the focus the impact of angiogenic and antiangiogenic factors on placental development. Development of the placenta in the first trimester of pregnancy is one of the main factors on which the further course and outcome of pregnancy depend. Factors of vascular endothelial growth (VEGF) and placental growth (PlGF) are key factors in both physiological and pathological conditions. VEGF and PlGF exert their activity through their receptor (tyrosine kinase) VEGFR-1 (Flt-1) and VEGFR-2 (KDR), located in endothelial cells. Oxygen is the principal regulator of the balance of VEGF and PlGF. Hypoxia reduces the action of PlGF, and hyperoxia increases. Soluble VEGFR-1 (Flt-1) is elevated in pregnant women who will develop preeclampsia. Successful placentation leads to low resistance in the blood vessels due to the transformation of the spiral arteries. [ABSTRACT FROM AUTHOR]