干扰素 α-2b 抑制瘢痕形成的研究与热点.

BACKGROUND: Interferon is a kind of cellular regulatory substance similar to polypeptide hormone, which has a wide range of biological activities, such as antivirus, anti-proliferation, antitumor and immunomodulatory functions. OBJECTIVE: To review the effect of interferon α-2b to inhibit scar formation in multiple organs, so as to provide a theoretical basis for clinical treatment of scar and fibrosis diseases. METHODS: A computer-based online search of WanFang, VIP, CNKI, PubMed, Web of Science and Elsevier Science Direct databases was performed to retrieve papers published during 1950-2020 with the search terms of “IFNα-2b, interferon α-2b, fibroblasts, scar, hypertrophic scar, keloid” in Chinese and English, respectively. A total of 42 papers were included for the final analysis. RESULTS AND CONCLUSION: Interferon α-2b can inhibit the occurrence and development of scar, reduce the production of extracellular matrix collagen, inhibit the proliferation of fibroblasts, and act on cytokines and gene targets related to fibrosis. Findings from this study provide a theoretical basis for the clinical application of interferon α-2b in the treatment of scar formation. [ABSTRACT FROM AUTHOR]