Back to Search
Start Over
Synthesis, crystal structure and antibacterial properties of 6-methyl-2-oxo-4-(quinolin-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate.
- Source :
-
Journal of Molecular Structure . Nov2020, Vol. 1219, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- The synthesis and investigation of a new biologically active derivative of dihydropyrimidine are reported. The structure of the synthesized compound was investigated by X-ray single crystal diffraction method. In order to understand the molecular interactions, the Hirshfeld surface and contacts enrichment analyses were performed. The crystal packing is mainly stabilized by strong N–H⋯O hydrogen bonds and aromatic cycle stacking. Among the different types of oxygen atoms, the most electronegative had the highest propensity to form H-bonds. Biological activity of the synthesized compound was studied against E.coli , P. aeruginosa and S. aureus bacteria. Image 1 • New Biginelli compound. • Conformational analysis. • Hirshfeld surface analysis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222860
- Volume :
- 1219
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Structure
- Publication Type :
- Academic Journal
- Accession number :
- 145438470
- Full Text :
- https://doi.org/10.1016/j.molstruc.2020.128581