Back to Search
Start Over
Characteristics of Systemic Sclerosis patients with positive anti-Th/To antibodies: About 6 patients and literature review.
- Source :
-
Revue de Médecine Interne . Jul2020, Vol. 41 Issue 7, p440-445. 6p. - Publication Year :
- 2020
-
Abstract
- Among the antibodies described in Systemic Sclerosis (SSc), anti-Th/To antibodies (anti-Th/To) are rare and have been poorly studied. Thus, little is known about the profile of anti-Th/To positive patients. From our local Biobank (Marseille, France), we retrospectively selected data for 6 patients positive for anti-Th/To with an Immunodot assay. All of them suffered from SSc, sharing clinical and biological common features such as a limited cutaneous form of SSc, a decreased lung diffusing capacity and a speckled nuclear nucleolar immunofluorescence pattern of antinuclear antibodies screening on HEp-2 cells. In order to further characterize patients positive for anti-Th/To, we performed a thorough literature review. From 402 studied patients positive for anti-Th/To, we confirmed that these antibodies are associated with the limited cutaneous form of the disease (88% of the patients), and with an SSc related-pulmonary involvement (50%). The review analysis pointed out the rarity of the anti-Th/To with an estimated mean frequency of 3.4% of all SSc patients worldwide, their usual exclusivity with respect to the specific antibodies of scleroderma, and their high specificity (around 98%) for the diagnosis of SSc. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SYSTEMIC scleroderma
*IMMUNOGLOBULINS
*PATIENTS
*IMMUNOFLUORESCENCE
*LUNG diseases
Subjects
Details
- Language :
- English
- ISSN :
- 02488663
- Volume :
- 41
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Revue de Médecine Interne
- Publication Type :
- Academic Journal
- Accession number :
- 145412489
- Full Text :
- https://doi.org/10.1016/j.revmed.2019.12.020