血清维生素D和K水平和慢性胰腺炎患者骨质疏松 症相关性研究.

Objective To explore the correlation between vitamin D and K levels and osteoporosis in patients with chronic pancreatitis (CP). Methods Bone mineral density was determined using dual-energy X-ray absorptiometry. Faecal elastase was detected to evaluate pancreatic function. Nutritional evaluation included vitamin D and vitamin K. The association between investigated variables and bone mineral density were analyzed with logistic regression analysis. Results A total of 211 CP patients were enrolled (67% men； mean age 60 years old). In total, 18% of the patients had advanced CP, 56% suffered from pancreatic exocrine insufficiency, and 43% had alcoholic etiology. Vitamin D and K were deficient in 56% and 32% , respectively. Osteopenia was diagnosed in 42% and osteoporosis in 22%. In the multivariate analysis, female sex (2. 78)，age (£>/?= 1. 07 per year), and higher BMI ((9/? = 0. 84) were associated with the presence of osteoporosis. In male patients, the only factor associated with osteoporosis was vitamin K deficiency (= 4. 23). Conclusion The present data confirm a high rate of osteopathy in CP patients and highlight the relevance of vitamin K deficiency as the only factor associated with osteoporosis in male patients. [ABSTRACT FROM AUTHOR]