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Corona charged aerosol detector non-uniform response factors of purified alcohol ethoxylated homologues using liquid chromatography.
- Source :
-
Journal of Chromatography A . Sep2020, Vol. 1627, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- • HLIC CAD analysis of alcohol ethoxylated surfactants. • Isolation of homologues by semipreparative separation. • Determination of response factor of homologues. • Unexpected very different response factors. Surfactants are used in various applications: cosmetics, pharmaceuticals, petrochemicals, environmental, etc. Many of these compounds are polydisperse, and because of this intrinsic polydispersity, it is essential to have a universal detector with a uniform response to quantify them in a simple way. Indeed, Charged Aerosol Detector (CAD) was presented as a universal detector with a uniform response. Thus, in the present study, the CAD response, in a High-Performance Liquid Chromatography - CAD configuration (HPLC CAD), was evaluated using purified alcohol ethoxylated surfactants. A semi-preparative liquid chromatography step using a Hydrophilic interaction chromatography (HILIC) bare silica column (150 mm, 4.6 mm, 2.6 µm) was implemented to prepare eleven homologues of BrijC10, a nonionic surfactant. These homologues differed only by the number of ethylene oxide units. BrijC10 homologues were analyzed by HPLC CAD, using a HILIC bare silica column (150 mm, 2.1 mm, 2.6 µm) to determine the HPLC CAD response factors of purified homologues. From the calibration curves (from 100 to 500 mg.kg−1), their response factors were estimated: differences in response factors were observed and a maximum difference in response factors of 3.6 was obtained. Thus, it could be concluded that CAD hyphenated to HILIC separation did not present a uniform response for this homologue's distribution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00219673
- Volume :
- 1627
- Database :
- Academic Search Index
- Journal :
- Journal of Chromatography A
- Publication Type :
- Academic Journal
- Accession number :
- 145320125
- Full Text :
- https://doi.org/10.1016/j.chroma.2020.461402