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Isolation, semi-synthesis, free-radicals scavenging, and advanced glycation end products formation inhibitory constituents from Parmotrema tinctorum.
- Source :
-
Journal of Asian Natural Products Research . Oct2020, Vol. 22 Issue 10, p976-988. 13p. - Publication Year :
- 2020
-
Abstract
- Bioassay-guided separation of acetone extract from lichen Parmotrema tinctorum (Delise ex Nyl.) Hale led to the isolation of six major phenolic constituents (1–6). Compounds structures were established using NMR and mass spectral techniques. Further, to develop libraries on these scaffolds, a series of semi-synthetic derivatives were prepared (1a–1f, 2a–2b, 3a, 5a) and investigated for their free-radicals (2,2-diphenyl-1-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS)) scavenging and advanced glycation end products (AGEs) formation inhibitory activities. Amongst tested derivatives, 1a, 1d, 1e, 2a, and 5a showed strong ABTS scavenging potentials comparable to Trolox. In addition, these derivatives also manifested moderate AGEs formation inhibitory activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIOXIDANTS
*BIOCHEMISTRY
*BIOLOGICAL assay
*CARBOXYLIC acids
*CHROMATOGRAPHIC analysis
*HETEROCYCLIC compounds
*LICHENS
*PHENOMENOLOGY
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*PHENOLS
*PLANTS
*PHYTOCHEMICALS
*PLANT extracts
*ADVANCED glycation end-products
*FREE radical scavengers
*CHEMICAL inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 22
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 145282171
- Full Text :
- https://doi.org/10.1080/10286020.2019.1628024