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Clinical Characteristics of the Charles Bonnet Syndrome in Patients with Neovascular Age-Related Macular Degeneration: The Importance of Early Detection.
- Source :
-
Ophthalmic Research . 2020, Vol. 63 Issue 5, p466-473. 8p. - Publication Year :
- 2020
-
Abstract
- Purpose: We investigated the characteristics, prognosis, and clinical outcome of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD). Methods: Five hundred psychiatrically healthy patients with neovascular AMD were screened for CBS. The individuals that fulfilled the inclusion criteria were systematically interviewed using a structured questionnaire that covered the impact, prognosis, risk factors, phenomenology, symptoms, and knowledge about the syndrome. A control group of 45 patients was used for comparison. Demographic data, current medication, and ocular risk factors were collected in all patients. Results: Forty-five patients with CBS were identified. The majority of patients reported images that consisted of colored (62%) animals (44%) or faces (42%) that lasted for seconds (53%). Most patients reported a selflimited disease with a median duration of symptoms between 9 and 11.5 months, with only 7% knowing about CBS at symptom onset. The degree of visual deficit did not predict the characteristics, complexity, frequency, duration, or impact of visual hallucinations. One-third of patients reported negative outcome, which was associated with shorter duration of CBS (p = 0.023), fear-inducing images (p < 0.001), and impact on daily activities (p = 0.015). Conclusion: The prevalence of CBS in neovascular AMD patients is high and clinically relevant. Patients with recent onset of visual hallucinations and describing fear-inducing images are at greater risk for negative outcome. Periodic screening may minimize the negative consequences of this disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RETINAL degeneration
*SYMPTOMS
*DISEASE duration
*REPORTING of diseases
*SYNDROMES
Subjects
Details
- Language :
- English
- ISSN :
- 00303747
- Volume :
- 63
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Ophthalmic Research
- Publication Type :
- Academic Journal
- Accession number :
- 145277616
- Full Text :
- https://doi.org/10.1159/000506137