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Hepatoprotective Effects of Streptococcus thermophilus LM1012 in Mice Exposed to Air Pollutants.
- Source :
-
Journal of Medicinal Food . Aug2020, Vol. 23 Issue 8, p852-861. 10p. - Publication Year :
- 2020
-
Abstract
- In this study, we explored whether the use of Streptococcus thermophilus LM1012 (TL-LM1012) as a safe probiotic exerts hepatoprotective effects by suppressing oxidative stress and inflammation in vitro and alleviating aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) production in vivo. In a series of safety tests, TL-LM1012 was found to have a negative response to hemolysis and biogenic amines, as well as susceptibility to antibiotics. TL-LM1012 protected cell viability and suppressed cytotoxicity by inhibiting oxidative stress and induced heme oxygenase-1 and superoxide dismutase activity in a dose-dependent manner in diesel exhaust particulate matter (DEPM)-treated HepG2 cells. Moreover, proinflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-6, and IL-1β, were suppressed in DEPM-treated splenocytes. In DEPM-treated mice, oral administration of TL-LM1012 regulated AST, ALT, and LDH production in the serum after 14 days of treatment. These findings indicate that TL-LM1012, a safe probiotic, provides a potent preventive or therapeutic effect against liver disease caused by air pollution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1096620X
- Volume :
- 23
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Medicinal Food
- Publication Type :
- Academic Journal
- Accession number :
- 145237704
- Full Text :
- https://doi.org/10.1089/jmf.2019.4636