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Immune modulatory and antioxidant effects of locally administrated vitamin C in experimental periodontitis in rats.
- Source :
-
Acta Odontologica Scandinavica . Sep2020, Vol. 78 Issue 6, p425-432. 8p. - Publication Year :
- 2020
-
Abstract
- Background: Vitamin C is an important water-soluble vitamin with antioxidant and immune-modulatory actions. The aim of this study was to investigate the effects of locally applied vitamin C on alveolar bone resorption in rats with experimental periodontitis.Methods: Twenty-one male Sprague-Dawley rats divided into three groups with seven animals in each group: (1) control, (2) experimental periodontitis and 3) experimental periodontitis-local vitamin C treatment group. After ligature was removed, 50 μL vitamin C was locally administered into the subperiosteum of the buccal gingiva of periodontitis vitamin C (PvitC) group rats for three times in intervals of 2 days. At the end of the study, the animals were scarified, and serum and gingival samples were collected for analysis of serum IL-1β, oxidative stress index (OSI), CTX and malondialdehyde (MDA) levels and gingival MMP-8 immunostaining. Alveolar bone loss and attachment loss were determined based on measurements on histological sections obtained from rat mandibles.Results: Serum MDA and OSI levels which are related to the oxidative stress were significantly lower in the PvitC group as compared with those in the P group (p < .05). Serum CTX levels which are related to the bone resorption were significantly lower in the PvitC group as compared with those in the P group (p < .05). The numeric density of MMP-8-positive cells was significantly lower in the PvitC group compared to P group (p < .05). Alveolar bone loss and attachment loss were significantly lower in the PvitC group compared to P group (p < .05)Conclusions: The local vitamin C administration provided protection against inflammation-induced alveolar bone resorption by decreasing oxidative stress and inflammation-induced tissue breakdown vitamin C may be a therapeutic agent that can be used in periodontitis treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00016357
- Volume :
- 78
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Acta Odontologica Scandinavica
- Publication Type :
- Academic Journal
- Accession number :
- 145199861
- Full Text :
- https://doi.org/10.1080/00016357.2020.1734656