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Glycopolymer ornamented octa-arm POSS based organic-inorganic hybrid star block copolymer as a lectin binding ligand.
- Source :
-
Materials Science & Engineering: C . Nov2020, Vol. 116, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- In this study, a polyhedral oligomeric silsesquioxane-polycaprolactone (POSS-PCL)-cored octa-arm star-shaped glyco block copolymer (BCP), poly(ε-caprolactone)- b -poly(glucopyranose) (Star -POSS-PCL- b -PGlc) was successfully synthesized via the combination of ring opening polymerization (ROP) and MADIX (macromolecular design by interchange of xanthate) polymerization technique. Herein, initially octa(3-hydroxy-3-methylbutyl dimethylsiloxy) POSS (Star -POSS) was utilized to initiate the ROP of the ε-caprolactone to get octa-arm star-shaped Star -POSS-PCL. A successive bromination followed by xanthation of the synthesized Star -POSS-PCL polymer allowed us to further polymerize 3-O-acryloyl-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose (AIpGlc) via MADIX polymerization. Formation of the star-shaped block copolymer (BCP) was characterized using 1H NMR, FT-IR and DSC analyses. The morphology and the aqueous solution behavior of the St ar-POSS-PCL- b -PGlc were analyzed using FESEM, HRTEM and DLS analyses, respectively. The lectin-binding efficiency of the star-shaped BCP having different glycopolymer block length was studied using turbidimetry assay and fluorescence quenching titration (FQT) using photoluminescence spectroscopy (PL). Here, FITC labeled concanavalin A (FITC-Con A) was used as a model lectin. The cytotoxicity study of the star-shaped BCPs over the human fibroblast cells revealed the non-toxic nature of the BCPs which open up its great potential towards drug delivery vector. Unlabelled Image [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09284931
- Volume :
- 116
- Database :
- Academic Search Index
- Journal :
- Materials Science & Engineering: C
- Publication Type :
- Academic Journal
- Accession number :
- 145070532
- Full Text :
- https://doi.org/10.1016/j.msec.2020.111210