Associations of long-term exposure to air pollutants, physical activity and platelet traits of cardiovascular risk in a rural Chinese population.

Long-term exposure to air pollutants relate to increase risk of cardiovascular diseases that may be partially attributable to platelet dysfunction. Physical activity (PA) may attenuate inflammation to modulate platelet function. Thus, this study aimed to evaluate associations of air pollutants and PA with platelet traits of cardiovascular risk. A total of 31,282 participants were obtained from the Henan Rural Cohort (n = 39,259). The concentrations of particulate matter (PM) (PM with an aerodynamic diameter ≤1.0 μm (PM 1), ≤2.5 μm (PM 2.5), or ≤10 μm (PM 10)) and nitrogen dioxide (NO 2) were evaluated by using a spatiotemporal model incorporated into satellites data. Independent and combined effects of air pollutants and PA on platelet traits were analyzed by linear mixed models. Positive associations of PM 1 , PM 2.5 , PM 10 and NO 2 with platelet indices (mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR), the MPV to platelet counts (PLT) ratio (MPVP)) were observed, whereas negative associations of PM 10 and NO 2 with PLT or plateletcrit (PCT) were observed; negative interaction effects of PM 2.5 PM 10 and NO 2 and PA on MPV, PDW or P-LCR were found; negative interaction effects of PM 1 , PM 2.5 and PM 10 and PA on PCT were observed. Long-term exposure to air pollutants were related to increase platelet size and these associations were attenuated by increased PA, implying that PA is a costless and affordable method to decrease adverse effects on platelet traits in relation to air pollutants. Unlabelled Image • Associations of air pollution with platelet traits were assessed in rural regions. • Air pollutants related to increase in platelet size among rural Chinese adults. • Physical activity attenuated negative effect of air pollutants on platelet indices. [ABSTRACT FROM AUTHOR]