A New Mixed-Ligand Ni(II) Complex: Crystal Structure, Protective and Anti-Inflammatory Activities of its Nanoparticles on Acute Viral Myocarditis by Reducing the Release of Inflammatory Cytokines TNF-α and IL-1β.

By means of the mixed-ligand strategy, a new Ni(II)-bearing coordination complex [Ni(pda)(bimb)(H2O)](H2O)1.5(1, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine, H2pda = 4,4′-(pyridine-2,6-diyl)dibenzoic acid) is successfully obtained by the reaction of Ni(NO3)2·6H2O, bimb, and H2pda under hydrothermal reaction conditions. Furthermore, the nanoparticles of 1 (nano-1) with a size distribution of around 160 nm can be produced via a grinding method. In the section of biological research, we describe the anti-inflammatory activity of nano-1 on the acute viral myocarditis model. In the CVB3-induced acute viral myocarditis model, the treatment effect of nano-1 is evaluated by determining the mice survival rate and the CVB3 titer. The anti-inflammatory activity of nano-1 is determined by the ELISA assay of TNF-α and IL-1β levels in plasma. [ABSTRACT FROM AUTHOR]