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Efficacy and safety of oral hyoscine used for outpatient cervical ripening among primiparous women with term pregnancy.
- Source :
-
International Journal of Gynecology & Obstetrics . Sep2020, Vol. 150 Issue 3, p335-339. 5p. - Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>To assess the efficacy and safety of outpatient administration of oral hyoscine for cervical ripening.<bold>Methods: </bold>In a randomized controlled trial at a university hospital in Tehran between September 2017 and December 2018, 100 primiparous women with singleton pregnancy at 380 -400 gestational weeks and Bishop score of 5 or less were randomized to either routine expectant management (control group) or 10 mg of oral hyoscine twice daily for 1 week, followed by once daily for 1 week (hyoscine group).<bold>Results: </bold>Mean ± SD Bishop score in the hyoscine and control groups was, respectively, 1.19 ± 1.38 and 1.08 ± 1.70 at baseline, and 4.56 ± 2.87 and 2.76 ± 2.14 on admission for delivery (P=0.001). Duration of the first stage was 4.10 ± 5.49 hours in the hyoscine and 5.29 ± 6.48 hours in the control group (P=0.03). Duration of the second and third stages was, respectively, 0.52 ± 0.53 and 0.14 ± 0.25 hours in the hyoscine, and 0.59 ± 1.08 and 0.12 ± 0.15 hours in the control group. No adverse effects were reported.<bold>Conclusion: </bold>Administration of oral hyoscine in an outpatient setting was found to ripen the cervix with no clinically significant adverse drug reaction. IRANIAN REGISTRY OF CLINICAL TRIALS (IRCT20180819040830N1). [ABSTRACT FROM AUTHOR]
- Subjects :
- *DRUG side effects
*CLINICAL trial registries
*PREGNANCY
*RANDOMIZED controlled trials
*CONTROL groups
*RESEARCH
*INDUCED labor (Obstetrics)
*OUTPATIENT medical care
*THIRD trimester of pregnancy
*RESEARCH methodology
*MEDICAL cooperation
*EVALUATION research
*CERVIX uteri
*COMPARATIVE studies
*PARITY (Obstetrics)
*LABOR (Obstetrics)
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 150
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 145042459
- Full Text :
- https://doi.org/10.1002/ijgo.13089