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The Effect of Cholesterol on the Voltage-Current Characteristics of Tethered Lipid Membranes.
- Source :
-
Journal of Membrane Biology . Aug2020, Vol. 253 Issue 4, p319-330. 12p. - Publication Year :
- 2020
-
Abstract
- In this study, a lipid bilayer membrane model was used, in which the bilayer is tethered to a solid substrate with molecular tethers. The V-I characteristics of the lipid bilayers were found to be non-linear which suggests the presence of pores that are voltage-dependent. At high applied voltages, the conductance reached a limiting value, presumably indicating a limit on the maximum pore size. A decrease in the spacing between tethers (increasing tether density) caused a decrease in the membrane's conductance at high applied voltage, which is consistent with the maximum pore size being determined by the spacing between the tethers. The inclusion of 10 M% cholesterol within the membrane lipid caused a decrease in the membrane conductance. However, the inclusion of higher levels of cholesterol increased the membrane conductance. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222631
- Volume :
- 253
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Membrane Biology
- Publication Type :
- Academic Journal
- Accession number :
- 144951911
- Full Text :
- https://doi.org/10.1007/s00232-020-00130-5