ORMDL3 but not neighboring 17q21 gene LRRC3C is expressed in human lungs and lung cells of asthmatics.

Keywords: asthma; chromosome 17q21; epithelium; LRRC3C; ORMDL3 EN asthma chromosome 17q21 epithelium LRRC3C ORMDL3 1 5 5 07/29/20 20200801 NES 200801 Abbreviations AHR Airway hyperreactivity ASM Airway smooth muscle ATF6 Activating transcription factor 6 BAL Bronchoalveolar lavage GSDMA Gasdermin A GSDMB Gasdermin B IBD Inflammatory bowel disease LRRC3C Leucine rich repeat containing 3C ORMDL3 ORM1-like-3 PBMC Peripheral blood mononuclear cell SERCA2b Sarco/endoplasmic reticulum Ca2 + ATPase 2b SNP Single nucleotide polymorphism ZPBP2 Zona pellucida-binding protein 2 The chromosome 17q21 region has strong linkage to asthma in genetic association studies. The lung genotyping demonstrated that the rs2872507 GG (risk allele for asthma) was detected in 3/10 (30%) of the asthma lungs and 8/13 (61%) of the control lungs (Figure 1F), none of whose lungs expressed LRRC3C mRNA. [Extracted from the article]