雌激素和孕激素受体在粉刺性乳痈的表达及意义.

Objective: To investigate the expression and clinical significance of of estrogen receptor (ER) and progesterone receptor (PR) in patients with acne breast carbuncle, and analyze their correlation with inflammatory factors. Methods: The expression of ER and PR in the breast lesions was detected by immunohistochemistry in 80 cases of acne breast carbuncle admitted to our hospital from January 2017 to December 2018, and serum levels of IL-1β, IL-6 and TNF-α were detected by enzyme-linked immunosorption (ELISA) to analyze the correlation between the expression of ER and PR in the breast lesions and serum levels of IL-1β, IL-6 and TNF-α levels. Results: Compared with mastitis group and mammary dilatation group, the serum levels of IL-1β, IL-6 and TNF-α in the granuloma group and abscess group were significantly increased, and compared with the granuloma group, the serum levels of IL-1β, IL-6 and TNF-α in abscess group were also significantly increased (P<0.05). There was no significant difference in the serum levels of IL-1β, IL-6 and TNF-α between mastitis group and mammary expansion group (P>0.05). The expression levels of ER and PR in the mastitis group, mammary dilatation group, granuloma group and abscess group were successively reduced (P<0.05). The expression of ER and PR were negatively correlated with serum levels of IL-1β, IL-6, but showed no significant correlation with the serum TNF-α level in the mastitis group and the mammary dilatation group (P>0.05). The ER and PR expression in granuloma group and abscess group were significantly negatively correlated with the serum levels of IL-1β, IL-6, TNF-α (P<0.05). Conclusion: Acne breast carbuncle has low or loss expression of ER and PR, which were significantly correlated with the inflammatory factors and severity of disease [ABSTRACT FROM AUTHOR]