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New Clue: Prediction from Cell-Free DNA.

Authors :
Sanders, Yan Y.
Source :
Journal of Clinical Medicine. Jul2020, Vol. 9 Issue 7, p2307. 1p.
Publication Year :
2020

Abstract

The main challenge for a positive long-term outcome in lung transplantation is the lack of early detection for chronic lung allograft dysfunction (CLAD). With advancements in technology, an increasing number of studies demonstrate that cell-free DNA (cfDNA) in body fluids could be used as a marker for disease diagnosis, prognosis or monitoring response to treatment. A previous report from this journal found the joint assessment of cfDNA and CXCL10 from brochoalveolar lavage (BAL) could determine the subphenotypes of CLAD and predict lung transplant survival. This is an exciting attempt in monitoring the progress for lung transplant recipients. More studies and better understanding of cfDNA are needed to develop an accessible and reliable biomarker to monitor the progress of CLAD to improve the long-term survival for lung transplant recipients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20770383
Volume :
9
Issue :
7
Database :
Academic Search Index
Journal :
Journal of Clinical Medicine
Publication Type :
Academic Journal
Accession number :
144747771
Full Text :
https://doi.org/10.3390/jcm9072307