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Conditional and unconditional genome-wide association study reveal complicate genetic architecture of human body weight and impacts of smoking.
- Source :
-
Scientific Reports . 7/22/2020, Vol. 10 Issue 1, p1-11. 11p. - Publication Year :
- 2020
-
Abstract
- To reveal the impacts of smoking on genetic architecture of human body weight, we conducted a genome-wide association study on 5,336 subjects in four ethnic populations from MESA (The Multi-Ethnic Study of Atherosclerosis) data. A full genetic model was applied to association mapping for analyzing genetic effects of additive, dominance, epistasis, and their ethnicity-specific effects. Both the unconditional model (base) and conditional model including smoking as a cofactor were investigated. There were 10 SNPs involved in 96 significant genetic effects detected by the base model, which accounted for a high heritability (61.78%). Gene ontology analysis revealed that a number of genetic factors are related to the metabolic pathway of benzopyrene, a main compound in cigarettes. Smoking may play important roles in genetic effects of dominance, dominance-related epistasis, and gene-ethnicity interactions on human body weight. Gene effect prediction shows that the genetic effects of smoking cessation on body weight vary from different populations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BODY weight
*EPISTASIS (Genetics)
*GENE ontology
*BENZOPYRENE
*SMOKING
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 144708934
- Full Text :
- https://doi.org/10.1038/s41598-020-68935-x