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Synthesis of conjugates of closo-dodecaborate dianion with cholesterol using a "click" reaction.
- Source :
-
Russian Chemical Bulletin . Jun2020, Vol. 69 Issue 6, p1080-1084. 5p. - Publication Year :
- 2020
-
Abstract
- The nucleophilic ring-opening reaction of tetrahydropyran derivative of the closo-dode-caborate dianion with sodium azide in the presence of tetrabutylammonium bromide led to the novel azido-derivatives of[B12H12]2−. A Cu-catalyzed 1,3-dipolar [3+2] cycloaddition reaction of the closo-dodecaborate dianion azido-derivatives with alkynyl-cholesterol led to 1,4-disubstituted 1,2,3-triazoles with the closo-dodecaborate fragment at position 1. The resulting conjugates are potentially suitable for the development of liposomal drugs to selectively deliver boron into a tumor cell for boron neutron capture therapy of cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10665285
- Volume :
- 69
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Russian Chemical Bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 144673980
- Full Text :
- https://doi.org/10.1007/s11172-020-2870-z