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Synergistic hypolipidemic and hypoglycemic effects of mixtures of Lactobacillus nagelii/betanin in a mouse model.
- Source :
-
Tropical Journal of Pharmaceutical Research . Jun2020, Vol. 19 Issue 6, p1269-1276. 8p. - Publication Year :
- 2020
-
Abstract
- Purpose: To determine the nutraceutical effect of mixtures containing Lactobacillus nagelii/betanin on the carbohydrate and lipid metabolism of mice. Methods: Lactobacillus nagelii and betanin were isolated from the raw materials. These components were subsequently assessed for their anti-hyperglycemic and hypolipidemic activities, and administered individually or combined in normoglycemic and diabetic mice. These animals were subjected to a standard OGTT and given an atherogenic diet. Results: The combination of L. nagelii (2.0 × 109 CFU/mL) and betanin (30 mg/kg body weight) exerted a significant (p < 0.01) and prolonged reduction of postprandial blood glucose (30 - 120 min). Interestingly, a mixture of L. nagelii (1 ×107 CFU/mouse/day) with betanin (10 mg/kg body weight) administered for 30 days, produced favourable effects (p < 0.01) in the lipid profile of mice previously treated with an atherogenic diet. These mixtures significantly ameliorated (p < 0.01) hypoinsulinemia, hyperleptinemia and increased the levels of adiponectin. Conclusion: The simultaneous administration of L. nagelii and betanin in mice produced a beneficial change in blood glucose and lipids in mice, indicating a synergistic nutraceutical effect. However, there is a need to develop this therapy further for potential application in humans [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15965996
- Volume :
- 19
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Tropical Journal of Pharmaceutical Research
- Publication Type :
- Academic Journal
- Accession number :
- 144529521
- Full Text :
- https://doi.org/10.4314/tjpr.v19i6.23