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The (Broad-Sense) Genetic Correlations Among Four Measures of Inattention and Hyperactivity in 12 Year Olds.
- Source :
-
Behavior Genetics . Jul2020, Vol. 50 Issue 4, p273-288. 16p. - Publication Year :
- 2020
-
Abstract
- We estimated the genetic covariance matrix among four inattention (INATT) and four hyperactivity (HYP) measures in the classical twin design. Data on INATT and HYP symptom counts were obtained in mono- and dizygotic twin pairs (N = 1593) with an average age of 12.2 years (sd =.51). We analyzed maternal ratings of INATT and HYP based on the Conners' Parent Rating Scale (CPRS), the Strengths and Weaknesses of ADHD-symptoms and Normal-behavior (SWAN), and teacher ratings based on the Conners' Teacher rating scale (CTRS) and the ASEBA Teacher Rating Form (TRF). Broad-sense heritabilities, corrected for the main effects of sex and for random teacher rater effects, were large (ranging from.658 to.912). The results reveal pervasive and strong broad-sense genetic effects on INATT and HYP phenotypes with the phenotypic covariance among the phenotypes largely due to correlated genetic effects. Specifically between 79.9 and 99.9% of the phenotypic covariance among the HYP measures, and between 81.0 and 93.5% of the INATT measures are attributable to broad-sense genetic effects. Overall, the present results, pertaining to the broad-sense heritabilities and shared genetic effects, support the current genome-wide association meta-analytic approach to identifying pleiotropic genetic variants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00018244
- Volume :
- 50
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Behavior Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 144520969
- Full Text :
- https://doi.org/10.1007/s10519-020-10002-2