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Chronic stress influences nociceptive sensitivity of female rats in an estrous cycle-dependent manner.
- Source :
-
Stress: The International Journal on the Biology of Stress . Jul2020, Vol. 23 Issue 4, p386-392. 7p. - Publication Year :
- 2020
-
Abstract
- Exposure to chronic stress can influence nociception and further induce hyperalgesia. Whether stress modulation of pain in female animals occurs in an estrous cycle-specific manner is still unclear. We profiled the changes in nociception (thermal, mechanical, formalin-evoked acute and inflammatory pain) of female Sprague-Dawley rats after treatment with chronic unpredictable mild stress (CUMS) and investigated whether these changes occur in an estrous cycle-dependent manner. The results showed that CUMS female rats exhibited a lower mechanical withdrawal threshold in proestrus and estrus, a longer formalin-evoked licking time in metestrus and diestrus, but no changes in the latency time on the tail-flick test. The present study findings suggest that chronic stress induces mechanical and formalin-evoked acute hyperalgesia of female rats in an estrous cycle-dependent manner. Our studies showed that chronic stress increased nociceptive sensitivity of female rats. Furthermore females had different stress-induced pain responses in different estrous phases: mechanical hyperalgesia in proestrus and estrus, formalin-evoked acute hyperalgesia in metestrus and diestrus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RATS
*HYPERALGESIA
*COURTESY
*ESTRUS
Subjects
Details
- Language :
- English
- ISSN :
- 10253890
- Volume :
- 23
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Stress: The International Journal on the Biology of Stress
- Publication Type :
- Academic Journal
- Accession number :
- 144476279
- Full Text :
- https://doi.org/10.1080/10253890.2019.1687683