功能性核磁共振成像技术对原发性三叉神经痛患者脑功能的评估价值及 血清 IL-1β 茁、TNF-α 琢检测的临床意义.

Objective: To study the evaluation value of functional magnetic resonance imaging (fMRI) in brain function of patients with idiopathic trigeminal neuralgia (ITN) and the clinical significance of serum interleukin-1β(IL-1β) and tumor necrosis factor-α (TNF-α). Methods: A total of 50 patients with ITN who were treated in Stomatological Hospital Affiliated to Anhui Medical University from February 2017 to February 2019 were included in the study and recorded as ITN group. Another 50 healthy patients who received physical examination during the same period were recorded as healthy control group. Both groups were scanned by fMRI at rest. The levels of mean fractional amplitude of low frequency fluctuation (mfALFF), serumIL-1βand TNF-α in the two groups were compared. Results: The levels of mfALFF in the left middle occipital gyrus, inferior occipital gyrus, fusiformgyrus, calcinate fissure surrounding cortex, central paralateral gyrus, triangular inferior frontal gyrus, right dorsolateral superior frontal gyrus and left cerebellar region 1 in the ITN group were higher than those in the healthy control group (all P<0.05). In the ITN group, the mfALFF values of right superior temporal gyrus, right middle temporal gyrus, right inferior temporal gyrus, right central sulcus cover, right superior marginal gyrus, right inferior temporal gyrus, left anterior cingulate gyrus, paracingulate gyrus, left temporal polar and superior temporal gyrus were significantly lower than those in the healthy control group (all P<0.05). The levels of serumIL-1β and TNF-α in the ITN group were higher than those in the healthy control group (all P<0.05). Conclusion: The evaluation value of fMRI at brain function in resting state of patients with ITN is high. The elevated levels of serum IL-1βand TNF-α may be closely related to the pathogenesis of ITN, and it play a role in promoting the occurrence and development of the disease. [ABSTRACT FROM AUTHOR]