DESİGNİNG POLY-N-VİNYLPYRROLİDONE BASED HYDROGEL AND APPLİED HİGUCHİ, KORSMEYER-PEPPAS, HİXSON-CROWELL KİNETİC MODELS FOR CONTROLLED RELEASE OF DOXORUBİCİN.

The paper deals with water swollen and pH environment-sensitive hydrogels by means of stitching of poly-Nvinylpyrrolidone with average molecular weight 10 kDa and N,N`- methylene-bis-acrylamide by 1-20% (mass). Hydrogel`s swelling degree and kinetics and their structures were characterized by FTIR, NMR, SEM and TGA methods. Also, some mechanical, biocompatible and mucoadhesive properties of hydrogels were determined. Besides, hydrogels were immobilized by means of doxorubicin as a model preparation and various mathematical models of zero and first order, as well as laws of Korsmeyer -Peppas and Hixson- Crowell were applied to its release profile. Note that the drug proceeded in line with non-Fickian diffusion mechanism while the releaee profile is best fitted with the Higuchi square root model. [ABSTRACT FROM AUTHOR]