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Room‐Temperature Guerbet Reaction with Unprecedented Catalytic Efficiency and Enantioselectivity.
- Source :
-
Angewandte Chemie International Edition . 7/6/2020, Vol. 59 Issue 28, p11384-11389. 6p. - Publication Year :
- 2020
-
Abstract
- We report herein an unprecedented highly efficient Guerbet‐type reaction at room temperature (catalytic TON up to >6000). This β‐alkylation of secondary methyl carbinols with primary alcohols has significant advantage of delivering higher‐order secondary alcohols in an economical, redox‐neutral fashion. In addition, the first enantioselective Guerbet reaction has also been achieved using a commercially available chiral ruthenium complex to deliver secondary alcohols with moderate yield and up to 92 % ee. In both reactions, the use of a traceless ketone promoter proved to be beneficial for the catalytic efficiency. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RUTHENIUM
*KETONES
*ALKYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 144334701
- Full Text :
- https://doi.org/10.1002/anie.202004758