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Characteristics of Patients with Large-Cell Neuroendocrine Carcinoma of the Lung.
- Source :
-
Turkish Thoracic Journal / Turk Toraks Dergisi . May2020, Vol. 21 Issue 3, p150-155. 6p. - Publication Year :
- 2020
-
Abstract
- OBJECTIVES: Neuroendocrine tumors of the lungs are a clearly different group of tumors with definite ultrastructural, immunohistochemical, and molecular features. We reported and analyzed the incidence, clinicopathological features, surgery rates, responses to first-line therapy, and survival outcomes of this rare condition according to our lung cancer patient database. MATERIALS AND METHODS: We retrospectively collected the data of 62 patients who were histopathologically diagnosed with large cell neuroendocrine carcinoma of lung (LCNEC) between January 2010 and January 2016. RESULTS: The patients were predominantly (95%) men (male:female=59:3) with their average age being 60.3±8.6 years. Diagnosis was made by the fine-needle aspiration biopsy (NAB) in 7 patients, bronchoscopic transbronchial biopsy in 13, and surgery in 42. Nearly 43.5% of the patients presented with the tumor in the right upper lobe. Additionally, tumors of 46.8% patients could be observed in peripheral locations. Sixteen patients presented with stage 1, 17 with stage 2, 15 with stage 3, and 14 with stage 4. Median progression-free survival (PFS) was 29 months (SE: 12.2) (95% CI, 5.2-52.8 months). Progression-free survival (PFS) was significantly better in patients with low N, M0, early stage, p63 positive, and TTF-1 positive across the entire cohort. Overall survival (OS) was significantly better in patients with comparatively lower N, M0, low stage, and peripheral location. CONCLUSION: This study demonstrated a single-center experience with clinicopathologic factors and survival outcomes of LCNEC patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 21492530
- Volume :
- 21
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Turkish Thoracic Journal / Turk Toraks Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 144287910
- Full Text :
- https://doi.org/10.5152/TurkThoracJ.2019.180166