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Nuclear factor-κB: The enemy within
- Source :
-
Cancer Cell . Sep2004, Vol. 6 Issue 3, p203-208. 6p. - Publication Year :
- 2004
-
Abstract
- Numerous lines of investigation suggest that nuclear factor NF-κB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters, and the tumor microenvironment activate NF-κB. NF-κB proteins themselves and proteins regulated by it have been linked to cellular transformation, proliferation, apoptosis suppression, invasion, angiogenesis, and metastasis. Constitutively activated NF-κB is common in wide variety of tumors. Furthermore, there exists genetic evidence that NF-κB mediates tumorigenesis. Thus, suppression of NF-κB activation should be effective in the prevention and treatment of cancer. [Copyright &y& Elsevier]
- Subjects :
- *NF-kappa B
*TRANSCRIPTION factors
*TUMORS
*CARCINOGENESIS
*CARCINOGENICITY
*CANCER
Subjects
Details
- Language :
- English
- ISSN :
- 15356108
- Volume :
- 6
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Cancer Cell
- Publication Type :
- Academic Journal
- Accession number :
- 14426772
- Full Text :
- https://doi.org/10.1016/j.ccr.2004.09.003