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The G-Quadruplex/Helicase World as a Potential Antiviral Approach Against COVID-19.
- Source :
-
Drugs . Jul2020, Vol. 80 Issue 10, p941-946. 6p. - Publication Year :
- 2020
-
Abstract
- G-Quadruplexes (G4s) are non-canonical secondary structures formed within guanine-rich regions of DNA or RNA. G4 sequences/structures have been detected in human and in viral genomes, including Coronaviruses Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and SARS-CoV-2. Here, we outline the existing evidence indicating that G4 ligands and inhibitors of SARS-CoV-2 helicase may exert some antiviral activity reducing viral replication and can represent a potential therapeutic approach to tackle the COVID-19 pandemic due to SARS-CoV-2 infection. We also discuss how repositioning of FDA-approved drugs against helicase activity of other viruses, could represent a rapid strategy to limit deaths associated with COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00126667
- Volume :
- 80
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Drugs
- Publication Type :
- Academic Journal
- Accession number :
- 144261528
- Full Text :
- https://doi.org/10.1007/s40265-020-01321-z