基于AGEs/RAGE/NF-kB通路探讨老年性骨质疏松 症发病机制.

With the increasing aging of the population, the incidence of osteoporosis has leapt to the third place in the world's chronic diseases. Osteoporosis and its associated pain and high risk of fracture have become an important public health problems in China, including senile.The incidence of osteoporosis showes a significant upward trend with age. At this stage, the mechanism of SOP is mainly considered from the aspects of conventional bone metabolic signaling pathways, mechanical stress, cytokines, and non-coding RNA. Recent studies have found that accumulation of glycosylation end products in vivo activates the nuclear factor kappa B signaling pathway and induces oxidative stress inflammatory responses, which is thought to be a potential mechanism leading to aging-related tissue degradation. [ABSTRACT FROM AUTHOR]