骨代谢生化指标临床应用专家共识（2020）.

The bone metabolism biochemical markers included calcium and phosphorus metabolism indicators, bone formation markers,bone resorption markers, hormone and cytokine. The bone metabolism biochemical markers were derived from the bone, cartilage, soft tissue, skin, liver, kidney, small intestine, blood, endocrine glands, and so on. They were enzymes and hormones secreted by osteoblasts or osteoclasts, and the product or non-collagen proteins of metabolic bone collagen matrix. The bone metabolism biochemical markers could reflect the state of bone turnover promptly, with high sensitivity and specificity, it had been used in osteoporosis diagnosis, prediction of fracture risk, curative effect observation of drug treatment, and the differential diagnosis of metabolic bone disease. And it had important clinical significance in epidemiology, pathogenesis and drug research of osteoporosis.In this paper, the "Expert consensus on clinical application of biochemical indicators of bone metabolism(2019)"was revised, A total of 41 amendments were made, the classic literature was retained, some contents were deleted, and the literature for the past three years was added. The experimental reference range of the bone metabolism index were collected and sorted. [ABSTRACT FROM AUTHOR]