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Pericardial Adipose Tissue Volume Is Independently Associated With Human Immunodeficiency Virus Status and Prior Use of Stavudine, Didanosine, or Indinavir.

Authors :
Knudsen, Andreas D
Krebs-Demmer, Lisanne
Bjørge, Natascha I D
Elming, Marie B
Gelpi, Marco
Sigvardsen, Per E
Lebech, Anne-Mette
Fuchs, Andreas
Kühl, Jørgen T
Køber, Lars
Lundgren, Jens
Nordestgaard, Børge G
Kofoed, Klaus F
Nielsen, Susanne D
Source :
Journal of Infectious Diseases. 7/1/2020, Vol. 222 Issue 1, p54-61. 8p.
Publication Year :
2020

Abstract

Background Increased pericardial adipose tissue is associated with higher risk of cardiovascular disease. We aimed to determine whether human immunodeficiency virus (HIV) status was independently associated with larger pericardial adipose tissue volume and to explore possible HIV-specific risk factors. Methods Persons with HIV (PWH) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) Study and matched 1:1 on age and sex to uninfected controls. Pericardial adipose tissue volume was measured using cardiac computed tomography. Results A total of 587 PWH and 587 controls were included. Median age was 52 years, and 88% were male. Human immunodeficiency virus status was independently associated with 17 mL (95% confidence interval [CI], 10–23; P < .001) larger pericardial adipose tissue volume. Larger pericardial adipose tissue volume was associated with low CD4+ nadir and prior use of stavudine, didanosine, and indinavir. Among PWH without thymidine analogue or didanosine exposure, time since initiating combination antiretroviral treatment (per 5-year use) was associated with l6 mL (95% CI, −6 to −25; P  = .002) lower pericardial adipose tissue volume. Conclusions Human immunodeficiency virus status was independently associated with larger pericardial adipose tissue volume. Severe immunodeficiency, stavudine, didanosine, and indinavir were associated with larger pericardial adipose tissue volume. Persons with HIV with prior exposure to these drugs may constitute a distinct cardiovascular risk population. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00221899
Volume :
222
Issue :
1
Database :
Academic Search Index
Journal :
Journal of Infectious Diseases
Publication Type :
Academic Journal
Accession number :
143827026
Full Text :
https://doi.org/10.1093/infdis/jiaa057